Journal article

Boronate-Phenolic Network Capsules with Dual Response to Acidic pH and cis-Diols

J Guo, H Sun, K Alt, BL Tardy, JJ Richardson, T Suma, H Ejima, J Cui, CE Hagemeyer, F Caruso

Advanced Healthcare Materials | Published : 2015

Abstract

Dual-responsive boronate-phenolic network (BPN) capsules are fabricated by the complexation of phenylborate and phenolic materials. The BPN capsules are stable in the presence of competing carbohydrates, but dissociate at acidic pH or in the presence of competing cis-diols at physiological pH. This engineered capsule system provides a platform for a wide range of biological and biomedical applications.

University of Melbourne Researchers

Grants

Awarded by Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology


Awarded by Australian Research Council


Awarded by National Health and Medical Research Council


Awarded by National Heart Foundation Career Development Fellowship


Funding Acknowledgements

This research was conducted and funded by the Australian Research Council Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036). This work was also supported by the Australian Research Council under the Australian Laureate Fellowship (F.C., FL120100030) and Discovery Project (F.C., 130101846) schemes, and by a project grant from the National Health and Medical Research Council (C.E.H., Grant Number 1029249). C.E.H. was supported by a National Heart Foundation Career Development Fellowship (Grant Number CR 11M 6066). The work was also supported in part by the Victorian Government's Operational Infrastructure Support Program and Monash Biomedical Imaging. The authors acknowledge the Centre for PET at the Austin (Melbourne, Australia) for supply of the <SUP>64</SUP>Cu. J.G. is grateful for a scholarship from the Chinese government (by the China Scholarship Council) for outstanding self-financed students abroad. The authors acknowledge Dr. Yuan Ping, Dr. Nadja Bertleff-Zieschang, Mattias Bjornmalm, Yi Ju, Dr. Wei Zhu, Dr. Yunlu Dai, and Qiong Dai (Department of Chemical and Biomolecular Engineering, The University of Melbourne, Australia), and Dr. Mei Choy (Vascular Biotechnology, Baker IDI Heart and Diabetes Institute, Australia) for helpful discussions.